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A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling

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Because rapamycin, which extends mouse lifespan 31 , can reverse age-related diastolic dysfunction and restore a more youthful metabolome in the aged myocardium 32 , we next evaluated metabolomic changes in Young, Old Con, and Old mAb female-treated hearts