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According to FDA labeling, the common side effects include: Gastrointestinal effects (with frequencies varying by dose): Nausea (12-30% of patients, often most prominent during dose escalation) Diarrhea (7-22%) Vomiting (2-10%) Constipation (5-17%) Abdominal pain or discomfort (5-10%) Decreased appetite (5-10%) Dyspepsia/indigestion (2-9%) Gastroesophageal reflux disease (1-5%, more common in weight management indication) Eructation/belching (more common in weight management indication) These gastrointestinal symptoms typically occur early in treatment or following dose increases and often diminish over time as the body adjusts to the medication

When Zn was administered in addition to OLZ, the mean levels of these cytokines were considerably lower

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The Risk of "Extreme" Fasting: Longer fasts combined with GLP-1 therapy can lead to insufficient nutrient intake, which triggers muscle atrophy and a "yo-yo effect" once the medication is stopped