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Dosage should be split into two times a day, at least 3-4 hours apart

Results from observational, target trial emulation, Mendelian randomization, and preliminary controlled studies have reported benefits with GLP-1 RAs across multiple clinical targets including alcohol-,substance- and tobacco-use disorders, mood and psychotic disorders, binge-eating disorder, and major neurocognitive disorders

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In addition to glucose control and weight reduction, clinical studies suggest that GLP-1 receptor agonists such as semaglutide may also provide cardiovascular benefits in certain high-risk patients