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A comprehensive literature search was conducted using the MEDLINE database (PubMed) for English-language articles published up to May 2025 using combinations of key search terms including diabetes mellitus, diabetes, neuropathy, polyneuropathy, diabetic neuropathies, peripheral neuropathy, diabetic polyneuropathy, pathophysiology, diagnosis and treatment. Articles were selected that primarily focused on DPN, with emphasis on human studies addressing the pathophysiology, clinical presentation, diagnostic approaches and therapeutic interventions
Your digestive system absorbs only 20 to 30% of most oral vitamins due to breakdown in the stomach and limited transporter capacity
Indeed, several studies have investigated the use of GSH precursors and GSH-enhancing agents, such as N-acetylcysteine and alpha-lipoic acid, in the treatment of neural aging
When Wnt signaling declines with age, regeneration slows
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