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Notably, in contrast to the notion that division is the only trigger for GSDMD activation, full-length GSDMD (GSDMD-FL) is also capable of inducing liposome leakage by palmitoyl modification and forming a pore structure similar to that of the GSDMD-NT pore and triggering pyroptosis
Stopping prematurely often halts progress and may lead to the same symptoms recurring when treatment restarts
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