Ramsey LB, Balis FM, OBrien MM, Schmiegelow K, Pauley JL, Bleyer A, Widemann BC, Askenazi D, Bergeron S, Shirali A, Schwartz S, Vinks AA, Heldrup J (2018) Consensus guideline for use of glucarpidase in patients with high-dose methotrexate induced acute kidney injury and delayed methotrexate clearance
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15 The decrease in enzymes related to NAD + de novo synthesis is due to the inhibition of the activity of PPAR coactivator 1 (PGC-1), which is a crucial determinant of renal recovery from AKI
In this trial, the dosage of colchicine was 0.5 mg once daily for patients weighing up to about 154 pounds and 0.5 mg twice daily for those weighing over 154 pounds