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Researchers theorize that combining appetite regulation, insulin signaling, and energy expenditure may create a broader metabolic effect than GLP-1-based activity alone a concept central to why triple-agonist research continues gaining momentum
A Phase I trial of the small non-peptide GLP-1 receptor agonist danuglipron in 98 patients with type 2 diabetes found that it had a similar glucose-lowering ability as the clinically used GLP-1 receptor agonists and was well tolerated during the 4 week study period [43]
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