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Lipids Health Dis (2020) 19:164

Lopes J, Ferreira-Gonalves T, Ascenso L, et al

Sulforaphane (54) is a potent inducer of the Nrf2 transcription factor, has excellent blood brain barrier penetration (55), and might expand the size of the glutathione reservoir by increasing expression of GCL, the rate liming step in glutathione biogenesis

Based on preclinical literature reviews, Pickart and colleagues proposed broader genomic effects, suggesting that, in sequencing models, GHK-Cu may influence approximately 31% of genes altered during skin aging, shifting expression patterns toward a younger phenotype [1]