NAD+ investigation induces delayed autophagy in Neuro2a cells partially by increasing [PMID: 21833846] Laboratory literature summary: NAD+ investigation induces delayed autophagy in Neuro2a cells partially by increasing oxidative stress
This complex process means that conditions affecting the stomach or intestines can significantly impair B12 absorption, including pernicious anaemia, atrophic gastritis, previous gastric surgery, coeliac disease, Crohn's disease, and long-term use of certain medications (such as metformin, proton pump inhibitors, and H2 antagonists)
Animal research suggests several converging mechanisms: modulation of the nitric oxide pathway , upregulation of VEGF driving angiogenesis, interaction with the growth-hormone-receptor pathway , and modulation of inflammatory cytokines including TNF- and IL-6
Peters B, Hadimeri H, Wahlberg R, Afghahi H