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GH stimulation may theoretically encourage tumor growth, so this therapy is avoided in anyone with an active malignancy or a history of cancer that is not in complete remission
Some studies have found changes in TSH levels after starting GLP-1 or GLP-1/GIP therapy, which is why follow-up testing is important
Both have substantial research literature
Obesity is widely recognised as a chronic, relapsing condition, so it is not unexpected that stopping pharmacotherapy is followed by partial weight regain in many individuals
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