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To downregulate CYP8B1 expression level in liver, AAV-sh Cyp8b1 , which was provided by Prof

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Typically occurring between ages 45 and 55, perimenopause transition is characterized by fluctuating estrogen levels and declining ovarian function that initiate a cascade of physiological and psychological changes that extend far beyond reproductive health

The regional specificity of BDNF induction concentrated in areas critical for memory formation and executive function provided a mechanistic explanation for Semax's cognitive-enhancing properties and established the neurotrophin hypothesis as central to its pharmacology