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Researchers became interested in the fragment because it appeared to retain some of the signaling activity of the parent molecule while being far smaller and easier to work with

Mannfred A

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FIGURE 4 3.5 FOXO4-DRI inhibits FOXO4-P53 binding and promotes P53 phosphorylation To further elucidate the specific mechanism of FOXO4-DRI in anti-aging, we induced senescence in endothelial cells under OGD conditions and treated these cells either PBS or FOXO4-DRI