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310 Key mechanisms supporting DTP survival include chromatin reconfiguration mediated by histone-modifying enzymes, activation of stress-response and bypass signaling pathways such as IGF-1R, AXL and YAP/TAZ, and a shift toward oxidative or alternative nutrient metabolism, often coupled with enhanced mitochondrial ETC dependency, selective mitophagy and resistance to lipid peroxidation, which together mitigate therapy-induced apoptosis

This combination is less common for good reason

PMID: 33104445

Injecting sermorelin before bed amplifies this pulse rather than creating an off-cycle pulse during the day when somatostatin tone is higher