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The core pathology of type 2 diabetes is insulin resistance and beta cell failure, which leads to imbalance of energy distribution: reduced glucose uptake by muscle and adipose tissue, increased gluconeogenesis in liver, and increased glucose and free fatty acid (FFA) levels in blood
The flip side is a BBB profile that tells a different story
514,515 Nusinersen, a modified ASO targeting the intronic splicing silencer N1 of the SMN2 gene, promotes the production of the full-length SMN protein
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