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Nearly a century ago, the formation by astrocytes of a protective barrier around the fibrotic scar tissue that replaces damaged neural tissue at the lesion core after traumatic injuries was characterised by Pio del-Rio-Hortega and Wilder Penfield 58,59 and named gliosis of astrocytes
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A recent clinical study further confirmed that NSW disrupts 24-hour rhythms of PER2, PER3, BMAL1, and ESR2 in PBMCs, impairs the inverse correlation between PER2 and BMAL1, and alters PER1 and ESR1 expression patterns, highlighting a misalignment in the peripheral circadian network associated with NSW schedules 212
J Sports Med Phys Fitness 1998;38:281-5
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