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The ideology has its roots in the 1960s and 1970s, but exploded into the mainstream in the 2010s

However, in activated PSCs, liraglutide, a GLP-1R agonist, did not stimulate release of inflammatory cytokines/chemokines, however, it stimulated PSC proliferation, which was dependent on ERK activation

Results showed dose-dependent weight loss: the 0.25mg dose produced 4.5% additional weight loss beyond diet and placebo, the 0.5mg dose achieved 9.2% weight loss, and the 1.0mg dose resulted in 10.6% weight lossrepresenting approximately twice the efficacy of other approved obesity drugs available at that time

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