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The regulatory landscape for compounded GLP-1 products has changed materially since early 2025, with the FDA resolving both semaglutide and tirzepatide shortages and ending temporary enforcement discretion periods
Beebe, D.C., Y.-B
The FDA has pointed to real problems with compounded GLP-1s: dosing errors from patients measuring their own doses out of multi-dose vials (some serious enough to require hospital care), counterfeit or mislabeled products sold online, and products that arrived warm or were stored incorrectly
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