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However, its crucial to understand that no IV glutathione product is FDA-approved for skin lightening in any major regulatory jurisdiction, and the only placebo-controlled clinical trial showed poor efficacy with serious safety concerns

These adverse effects have prompted the Food and Drug Administration of Philippines to issue a public warning regarding the safety of the off-label use of glutathione injection as a skin-lightening agent.[] L-Cysteine peptide L-Cysteine peptide is another remarkable antioxidant which may be used for the treatment of melasma owing to its skin-lightening property

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