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Hy kin nhn v nht qun vi liu lng v thi quen b sung chn
Malate is transported to the interior of the mitochondrion via the 2-oxoglutarate/malate antiporter
Compound 78 showed excellent potency, engaging key residues such as Y683 in the PDE10A selectivity pocket, but it still exhibited a poor pharmacokinetic profile, low aqueous solubility, and off-target ion channel activity against hERG
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