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Oral vs Injectable BPC-157: Whats the Difference

It has been reported that an average of 630% of patients could show vitamin B12 deficiency due to metformin use.[] As per UK MHRA, decreased vitamin B12 levels, or vitamin B12 deficiency, are now considered to be a common side effect in patients on metformin treatment, especially in those receiving a higher dose or longer treatment duration and in those with existing risk factors

For example, patients with conditions like pernicious anemia or significant absorption issuessuch as those caused by gastrointestinal disorders (like Crohns disease or celiac disease), a history of gastric surgery, or certain long-term medicationsoften require higher or more frequent doses, especially when starting treatment

Acta Pharm Sin B 13(2):577597