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Major Differences to Consider Receptor Activation Retatrutide: GLP-1 + GIP + glucagon Semaglutide: GLP-1 only Expected Weight Loss Retatrutide: Potentially greater reductions Semaglutide: Strong but less dramatic Side-Effect Profile Retatrutide may produce more intense gastrointestinal symptoms early on due to its multi-receptor activation
If semaglutide leads to significant weight loss, it could change the muscle mass or fat distribution in the areas where Botox is injected, potentially altering the aesthetic results
This reinforces the importance of looking beyond a single point-in-time measure, Poulopoulos said, noting that underwriters increasingly consider broader indicators of metabolic health and weight history rather than current BMI alone
doi:10.1016/0092-8674(90)90815-v
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