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We selected SGLT-2 inhibitors and DPP-4 inhibitors as active comparators, because they are used at a similar disease stage as GLP-1 and are not associated with the outcome
We conducted a systematic review and meta-analysis to evaluate the effects of the addition of GLP-1RA to SGLT2i in patients with type 2 diabetes mellitus and inadequate glycemic control
By activating both GIP and GLP-1 receptors, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying
Delayed stomach emptying may also influence the absorption of oral medications
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