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[9] [10] Biochemistry [edit] In the rate-limiting step of the methyl cycle, MTHFR irreversibly reduces 5,10-methylenetetrahydrofolate (substrate) to 5-methyltetrahydrofolate (product)

Once you exceed approximately 200mg in oral form, absorption rates drop dramatically, and excess amounts are simply excreted

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For example, Parkinsons and Alzheimers diseases have high levels of oxidative stress and damage to the brain with correspondingly low active glutathione (GSH) levels