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Although the CLP-induced AKI model is similar to the clinical pathogenesis, the challenge of standardizing the process could result in variations in AKI models between studies, as well as a higher risk of infection and less repeatability in the CLP model

[PMID: 9503152] Laboratory literature summary: Is the glutathione S-conjugate pump a flippase

GHK-Cu treatment reduced reactive oxygen species (ROS) production, increased superoxide dismutase (SOD) activity, and decreased TNF- and IL-6 production by inhibiting NF-B p65 and p38 MAPK signaling in LPS-induced macrophages and ALI models

Antioxidants can deactivate unstable free radicals resulting from trauma or surgery, thereby playing an important role in the prevention of further damage