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However, in vitro studies have yet to find a direct effect of metformin on the activity of DPP4 [58], suggesting that any effect of metformin on DPP4 activity may be indirect, possibly by influencing hepatic production of DPP4 [56, 64]
Thus, Homocysteine is regarded as a pro-inflammatory amino acid that induces the expression of different transcription factors and the release of pro-inflammatory cytokines (Meng et al
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