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If your B12 deficiency is severe, it could take 4-6 weeks of injections before you really start to turn the corner and feel like your old self again

Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration

But even with half-unit syringes, reconstitution volume matters: a 2mg dose from a 50mg/mL concentration requires 0.04mL (4 units)

How Soon May I Feel Results After Starting Vitamin B12 Injection Dosage For Adults