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347 On the basis of compounds that bind to amyloid proteins, L 1 and L H have been designed
The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below
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G., Alarcon, R
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