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Current clinical evidence supports the safety of GLP-1 medications over extended periods, with large trials running up to several years showing sustained benefits and a well-characterized side effect profile
However, GLP-1RAs are usually modified analogues that are designed to be much longer acting, with a therapeutic window of up to 1 week, and their use is rapidly becoming a key treatment for patients with type 2 diabetes as well as those with a requirement for weight loss
Here are the results: Dose-dependent weight loss The phase 2 trial showed a dose-dependent relationship between retatrutide and weight loss
