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Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance
For instance, the pleckstrin homology domain interacting protein (PHIP) protein acts as a transcriptional co-regulator that directly modulates POMC transcription, whereas the SIM1 transcription factor is indispensable for the normal development of the PVN and the proper expression of MC4R [8,13]
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It is very unlikely to apply to retatrutide for obesity management at this stage
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