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This is particularly relevant for patients with pernicious anaemia, where intrinsic factor deficiency prevents adequate oral absorption
Depending on your product, unmixed (dry) methylcobalamin vials should be stored following product instructions
Reported weekly weight-loss differences over placebo were small (in the range of -0.06 to -0.15 kg/week, depending on dose)
About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted
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