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Some considerations and risks of long-term use include metabolic effects that could be changes in insulin sensitivity and cardiovascular effects that could shift blood pressure or lipid levels in vulnerable individuals
[53] The trials were conducted at 673 sites in 24 countries, including Argentina, Australia, Brazil, Canada, India, Israel, Japan, Mexico, Russian Federation, South Korea, Taiwan, European Union, and the United States (including Puerto Rico)
367 Moreover, LDH-targeted therapy can also achieve therapeutic effects when used in combination with adjuvant therapy
The six inhibitors are classified into three types based on their different binding to the active site of the DPP-4 enzyme
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