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However, the hepatitis C virus NS3/4A protease localizes to both organelles but exhibits distinct cleavage efficiencies, effectively dismantling MAVS at these spatial hubs to truncate the innate immune response, and the causality was established through MAVS knockout followed by the lentiviral overexpression of organelle-restricted MAVS constructs (MAVS-pex and MAVS-mito) (87)
The safety and efficacy data in this population is limited because clinical trials specifically excluded them
When these signals are better balanced, patients may notice they are less likely to overeat, snack frequently, or feel out of control around certain foods
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