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The Race to Produce Longer-Lasting Drugs Because Byetta had to be injected twice daily, drug companies began searching for longer-lasting GLP-1 medications
The medical community widely adopts this dose as the end point of the standard titration protocol, where patients gradually escalate over 16-20 weeks before maintaining on the highest dose indefinitely
The improvements in HbA1c and weight loss were also clinically meaningful, the former reflecting evidence from DCCT/EDIC 2,3 and the latter meeting the minimum weight loss (5%) needed for metabolic improvement 41
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