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AIMS Biophys

Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

Moreover, these alterations were accompanied by an angiogenic response in the prelimbic PFC (PL-PFC) and somatosensory cortex, evidenced as an increase in the area occupied by microvessels (Occhieppo et al., 2017