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Most clinical use is based on extrapolation from animal research and anecdotal reports from clinical practice
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It is synthesised in the body, and the extent to which it is a required dietary component under normal circumstances is unclear
The reversible reaction i.e., deglutathionylation, occurs either by the intervention of Grxs or by direct thiol/disulfide exchange reactions with GSH once an appropriate GSH/GSSG ratio has been restored
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