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Major limitations, before their large-scale clinical application, are still represented by: (i) appropriate quality control for CNS biocompatibility and safety, including their complete, efficient and fast clearance/reabsorption, (ii) establishment of the ideal mechanism of NP-mediated drug delivery into the brain, and (iii) a careful consideration of the multiple factors that may affect NP efficacy into the brain microenvironment, such as the ideal material, size and shape, surface modification
Not to mention, decreased weight can allow us to be more active, a win-win for weight loss and health
That means avoiding the all-or-nothing mindset that leaves people burned out and disappointed
As with any medication, they can have side effects
