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The usual dose is 1000 micrograms (mcg)
Weeks 1 to 2 (loading phase): Most patients notice reduced pain and inflammation before they notice structural improvement
Severe deficiency may lead to anaemia or nerve damage
[2] High-dose intramuscular administration creates a tissue depot that releases vitamin D slowly over weeks, potentially enabling a single injection to lift serum 25-hydroxyvitamin D levels into the sufficient range in severe deficiency and to potentially support bone mineralisation, neuromuscular function, and secondary hyperparathyroidism reversal while bypassing the gastrointestinal tract
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