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Real-world outcomes: According to a 72-week phase 3b trial, adults with obesity (but without diabetes) treated with tirzepatide were significantly more likely to lose at least 10% or 15% of their body weight than those treated with semaglutide
2 And those with high coinsurance and copays may be less likely to fill prescriptions for GLP-1s as directed
Avoid drinking alcohol, as this will make the sleepiness much worse
The decreased production of estrogen in patients receiving GLP-1RA inhibits the collagen synthesis and increases the activity of metalloproteinase-1, leading to matrix collagen and elastin degradation
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