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Fallacy 3: MTHFR Means You Cant Process Folic Acid One of the most widespread misconceptions is that carrying an MTHFR C677T or TT polymorphism means you cannot process folic acid
Hydroxocobalamin 1mg is the standard UK formulation, typically administered every two to three months for maintenance therapy Self-administration requires GP prescription, competency training from practice nurses, and demonstration of proper injection technique Common injection sites include the thigh (vastus lateralis) for both intramuscular and subcutaneous administration with site rotation essential Serious side effects are rare but anaphylaxis requires immediate 999 call
In the Phase 3 TRIUMPH-4 trial, 33% of participants on the 12 mg dose reported diarrhea compared to 13.4% on placebo (Wang et al., Syst Rev Meta-Analysis, 2025)
As always, it is advisable to consult with a healthcare professional before starting any new supplement regimen.
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