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It was originally isolated in 1977 from the cerebral venous blood of rabbits and has since been found to be present in small amounts in human brains and plasma, with higher concentrations later in the day.3 4 It, or a similar substance, is also present at higher concentrations in human breast milk.5 Because DSIP can cross the blood-brain barrier and is easily absorbed via the gut (unusual for a peptide), some researchers have hypothesized that it may facilitate post-feeding sleep tendencies among newborns, though it remains unclear whether DSIP truly has a hand in neonate sleep-wake cycles.4 5 6 Its mechanism of action is likewise unclear, but it may have something to do with endocrine regulation
Patients with overweight, obesity, or metabolic syndrome risk factors such as hyperglycemia and dyslipidemia, should be screened for NAFLD by starting with a liver enzyme panel If NAFLD is present, sustainable lifestyle modifications including therapeutic dietary and exercise interventions should be implemented with regular follow up assessments Adding nutritional bioactives, such as glutathione, should be considered American Liver Foundation
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