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Besides depleting dNTP pools, SAMHD1 also has a direct role in maintaining genome integrity by promoting DNA end resection to facilitate double-strand break repair by HR 160
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Graves, Kevin Camphausen, Hyo-Jin Kim Chemotherapy.2012
Furthermore, diosgenin induced apoptosis in the colon cancer cell lines HT-29 and HCT-116 in vitro by interfering with COX-2 signaling and increasing DNA fragmentation, caspase-3, and 5-lipoxygenase activity (244)
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