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Assemblies formed in the presence of the peptide are described as less stable or slower to form, and in vitro assays typically catecholamine release from chromaffin cells, the classical model system for SNARE-dependent exocytosis have been reported to show reduced stimulated release under peptide exposure
J Cell Mol Med (2020) 24(8):464658
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These results are new and shed light on the reasons for high rates of early discontinuation of semaglutide for weight loss in a real-world setting, said Professor Thomsen
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