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For the colorectal cancer PDX study, female NCR nude mice (CrTac:NCr- Foxn1 nu from Taconic) were implanted subcutaneously with low-passage KRAS-mutant CRM 13180 tumour fragments (30 mg) into the region of the right axilla
A single overnight room-temperature excursion (approximately 8-12 hours at 20-25 degrees Celsius) is unlikely to cause significant degradation if the medication is otherwise within its expiration date and has been properly stored
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