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wustl.edu Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins As a physician-scientist, David Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage

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10.2337/diabetes.52.12.2874 43 SaiharaK.KamikuboR.IkemotoK.UchidaK.AkagawaM

In an effort to eradicate the infection, phagocytic cells flood the area where H