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398 Zhou, H
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Binding-affinity work using peptidomimetic secretagogue derivatives has characterized Ipamorelin and related structures at the ghrelin receptor, including their use as reference ligands in receptor-imaging probe design [4]
The NF-B pathway is activated by pro-inflammatory factors such as TNF- and IL-6 [24], enhancing transcriptional activity through receptor-mediated downstream signaling cascades, inducing the expression of E3 ubiquitin ligase genes atrogin-1 and MuRF1, thereby driving muscle protein degradation via the UPS [25]
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