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Observed reductions in BP after 68 weeks of CagriSema treatment versus placebo were greater than those previously observed over the same time frame for semaglutide 2.4 mg in participants with overweight or obesity in the Semaglutide Treatment Effect in People with Obesity (STEP) 1, STEP 3, and STEP 4 trials, with an overall reduction in SBP versus placebo across the 3 trials of 5.0 (95% CI, 5.9 to 4.1) mm Hg

A properly balanced GI microbiome is absolutely crucial for optimal GI function, immune function, and brain function

Using the medication past this date can lead to reduced effectiveness or other issues: Expired Medication: Even if the vial looks fine, using semaglutide past its expiration date is not recommended

Ongoing clinical trials and future directions To definitively answer whether GLP modulation offers true disease-modifying benefits, the field must rely on ongoing prospective trials (93, 103, 110)