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We used our model for APAP metabolism, integrated with our model for GSH metabolism[9] to compute the concentration of hepatic GSH and the amount of covalent binding of NAPQI after various doses of APAP

We mentioned earlier that Indena, the company that makes Siliphos, has conducted its own studies into its efficacy, the highlights of which are:64 Bioavailability: Oral Siliphos was found to absorb into the bloodstream and be analytically detectable within minutes, and then remain stable within plasma for over six hours

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