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KPV, the C-terminal tripeptide of -MSH (Lys-Pro-Val), has been investigated for its interaction with NF-B signaling, with researchers observing inhibition of NF-B nuclear translocation and downstream inflammatory cytokine expression (TNF-, IL-6, IL-8) in cell culture models
Western Blot Analysis Gastrocnemius muscle samples were homogenized in RIPA lysis buffer (ServiceBio, Wuhan, China) containing a 50 protease inhibitor cocktail (ServiceBio, Wuhan, China)
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10.1016/j.cryobiol.2020.03.008 7
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