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Reviewed by: WPG Research Team, Health & Wellness Editor Last Updated: February 7, 2026 | Sources: NEJM, Nature Medicine, Eli Lilly, FDA.gov, ClinicalTrials.gov The Bottom Line on Retatrutide Retatrutide shows among the highest weight loss results reported in any Phase 3 obesity drug trial to date (~28.7% body weight at 68 weeks)
Image Credit: Love Employee / Shutterstock In a recent study published in the journal BMJ Medicine , researchers conducted a target trial emulation to assess associations between different scenarios of glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment and the risk of major adverse cardiovascular events (MACE)
Since both medications belong to the same class (GLP-1), they work in similar ways, but switching may require adjustments to your dosage and monitoring for potential side effects as your body adjusts
If you cannot find Wegovy at the higher weight-loss doses (1.7 mg or 2.4 mg), some physicians prescribe Ozempic at equivalent doses instead
