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When erastin and/or the iron compound ferlixit were used to induce ferroptosis in HEY, COV318, PEO4 and A2780CP ovarian cancer cell lines, it was found that erastin treatment was accompanied by NCOA4-mediated ferritin phagocytosis and mitochondrial dysfunction in HEY cells with high intracellular unstable iron pools (58)
This vicious cycle may have profound long-term implications for the physical, mental, and economic health of our nation and the millions struggling with obesity
C.DobbinsJ
doi:10.3390/biomedicines11041027
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